Fibro-adipogenesis in Injured Rotator Cuff Muscle

Abstract Purpose of Review Fibro-adipogenic progenitors were first characterized in 2010 and later found to contribute significantly muscle regeneration mediate degenerative changes following injury. These also have an influence on the rotator cuff muscle’s response chronic injury which is defined by fibrosis accompanied massive fatty degeneration. The purpose this review highlight progenitor cells, their contribution fibro-adipogenesis tissue, factors influencing tissue. Recent Findings are a key mediator infiltration notably prevalent Relative other groups, has relatively high rates tears. This may be linked pre-injury density fibro-adipogenic tissue affecting post-injury levels fibro-adipogenesis. In addition, suprascapular nerve rat models tears demonstrated worse, histologic, biomechanical properties lower healing repairs. However, compression been shown reversible release compression. Summary acute determined complex array including cell influence, transcriptional pathways, chronicity injury, anatomic location microenvironmental influences, severity involvement. Elucidating interactions these will provide potential targets for therapeutic intervention vivo.